Proteome allocation influences population dynamics in microbial communities

Leonardo Pacciani-Mori, Andrea Giometto, Samir Suweis, Amos Maritan

Published in bioRxiv, 2020

Recommended citation: Pacciani-Mori L., Giometto A., Suweis S. and Maritan A. (2019). "Proteome allocation influences population dynamics in microbial communities", bioRxiv. DOI: 10.1101/2020.01.27.921478

Preprint website

Abstract

Microbial communities are complex systems, and the fundamental mechanisms that control their dynamics and composition are still largely unknown. Here we show that such systems have a previously unexplored level of complexity: their microscopic details related to gene expression influence their macroscopic properties such as the population dynamics. We provide an experimental proof of concept showing that proteome allocation dramatically affects the outcome of competition assays between strains of Escherichia coli. We also provide an essential model that predicts our findings.